| Gregory Isaacs | Dreaming (Edit) | Dreaming (3) | Top Secret Music | 2022 |
| Gregory Isaacs | Please Forgive Me | Lion Pride (1) | Upsetta | 2017 |
| Gregory Isaacs | Love You | Grass Root | Free Willy | 2015 |
| Gregory Isaacs | False Evidence | I Was Born To Be Loved | Blacker Dread | 2010 |
| Gregory Isaacs | Mr Brown | Mr. Brown | Tad's | 2010 |
| Gregory Isaacs | Fools Fall In Love | Fools Fall In Love | Tad's | 2009 |
| Gregory Isaacs & Blackout JA | Innercity Lady | Innercity Lady | Necessary Classics | 2009 |
| Gregory Isaacs & Blackout JA | Report To Me | Rumours | Necessary Mayhem | 2009 |
| Gregory Isaacs | 12 Tribe Dance | Zion Way (2) | VIS | 2008 |
| Gregory Isaacs & Big Star | Touch Not | Binghi | M Records | 2008 |
| Gregory Isaacs | Dismiss | The Creeper | Enrapture | 2007 |
| Gregory Isaacs | Nagging Me | Samara | Supatech | 2007 |
| Gregory Isaacs | Counterfeit Lover | Hype Time (1) | Strictly Roots | 2006 |
| Gregory Isaacs | Curfew | Crank Angle | Rockers | 2006 |
| Gregory Isaacs | Mail Box | Strange Things | Go-On | 2006 |
| Gregory Isaacs | Save Ethiopia | Rastar | Rastar | 2006 |
| Gregory Isaacs | Spot And Beat The Bank | Fisherman | Congo Music Works | 2006 |
| Gregory Isaacs | www.love.com | Quick Pick | Run Things | 2006 |
| Gregory Isaacs | Bumping And Boring | Early In The Morning | Vizion Sounds | 2005 |
| Gregory Isaacs | Crack Head | Hard Drugs | Tad's | 2005 |
| Gregory Isaacs | Gone A Jail | I Hold The Handle | Free Willy | 2005 |
| Gregory Isaacs | Hard Drugs | Hard Drugs | Tad's | 2005 |
| Determine & Gregory Isaacs | Murderers | Hit The Road Jack | Free Willy | 2005 |
| Gregory Isaacs & Macka Diamond | Number One | Number One | Ballafire | 2005 |
| Gregory Isaacs | Paymaster | Paymaster | Observer | 2005 |
| Gregory Isaacs | Almost 2 O'Clock | Better Place | Jungle Jimuzik | 2004 |
| Gregory Isaacs | Best Dressed Lady | Craven Dog | Stingray | 2004 |
| Gregory Isaacs & Sugar Roy | Forward | Soon Forward | Fire Ball | 2004 |
| Gregory Isaacs | Margaret | Messer Banzani | Germaican | 2004 |
| Gregory Isaacs | My Kind Of Lady | Heptones Gonna Fight | Big Man | 2004 |
| Gregory Isaacs & Screechie Joe | No Charge | Father Jungle Rock | Free Willy | 2004 |
| Gregory Isaacs & Don Abi | Reason For Love | Rudie | Nitty Gritty | 2004 |
| Gregory Isaacs | What A War | New Broom | Stingray | 2004 |
| Gregory Isaacs | Will You Be Mine | Marathon Man | Jammy's | 2004 |
| Gregory Isaacs | Yes Baby | Vanity | Mun Mun | 2004 |
| Gregory Isaacs | You And Your New Lover | Valentine | Germaican | 2004 |
| Gregory Isaacs | 15 Mins Ago | Ain't Nobody Else | Penthouse | 2003 |
| Gregory Isaacs | Don't Dis The Dance | Ba Ba Boom | Black Scorpio | 2003 |
| Gregory Isaacs | Heartbreaker | Everything Green | Sa Dos | 2003 |
| Gregory Isaacs | My Baby | Real Iron | Blacker Dread | 2003 |
| Gregory Isaacs & Ras Myrhdak | One Step Away | Prison Oval Rock | Binggae | 2003 |
| Gregory Isaacs | Wha Dee Wha Da | Revival Dub | Black Scorpio | 2003 |
| Gregory Isaacs | Josephine | Dalla Sign | CJ | 2002 |
| Gregory Isaacs | Looking At Love | Hit Song | Notorious | 2002 |
| Gregory Isaacs | Nah Lef The Dance | Mud Slide (1) | Geezy | 2002 |
| Gregory Isaacs & Shad Du | New Love | Gun In A Baggy | Shocking Vibes | 2002 |
| Gregory Isaacs | New Lover | Columbus | Cave | 2002 |
| John Holt & Gregory Isaacs | Roman | A Love I Can Feel | African Museum | 2002 |
| Gregory Isaacs | Save Some Loving | Vibration (1) | CPR-1 | 2002 |
| Gregory Isaacs | Seeing Is Believing | Raggamenta | RD's | 2002 |
| Gregory Isaacs | Why Is My Baby Going | Answer | Penthouse | 2002 |
| Gregory Isaacs | Cool & Deadly | Under Jah Rock | VIS | 2001 |
| Buju Banton & Gregory Isaacs | Hang On | Great Storm | Penthouse | 2001 |
| Gregory Isaacs | Josephine | Ease Up (2) | Survival | 2001 |
| Gregory Isaacs | Mr Brown | Mr. Brown | Penthouse | 2001 |
| Gregory Isaacs & Marcia Griffiths | Number One | Number One | Penthouse | 2001 |
| Gregory Isaacs | Roses In Your Garden | Mr. Sin-A-Man | Checkmate | 2001 |
| Gregory Isaacs | Sentence | Dance | Black Scorpio | 2001 |
| Gregory Isaacs | So Long Babe | Real Rock | — | 2001 |
| Gregory Isaacs | Storm | Great Storm | Penthouse | 2001 |
| Gregory Isaacs & Louie Culture | Tune In | Tune In | Cali Bud | 2001 |
| Gregory Isaacs | You're Gonna Lose Her | ~Unknown (143) | World Records | 2001 |
| Gregory Isaacs & Alozade | Call Di Police Pon Me | Razor Blade | Young Blood | 2000 |
| Gregory Isaacs | Dance With Me | Fi Wi Rock | Kingston 11 (2) | 2000 |
| Gregory Isaacs | Don't Go | My Conversation | Digital-B | 2000 |
| Gregory Isaacs | Informer | My Conversation | Stone Love | 2000 |
| Gregory Isaacs | Just Like A River | Just Like A River | African Museum | 2000 |
| Gregory Isaacs | Maximum Respect | Guess Who's Coming To Dinner | Heart To Heart | 2000 |
| Gregory Isaacs | Nught Nurse | Gal A Watch | Witty | 2000 |
| Gregory Isaacs | Save A Little Lovin For Me | Big, Bad & Bold | 2 Nice | 2000 |
| Gregory Isaacs | Tribal War | Rain From The Skies | RBM | 2000 |
| Gregory Isaacs | Winsome | Friends For Life | Black Scorpio | 2000 |
| Gregory Isaacs | Winsome | Bobo Dread | J.R. | 2000 |
| Gregory Isaacs | Coke Head | Family (1) | Black Scorpio | 1999 |
| Gregory Isaacs | Girls Of My Mind | Things And Time | Techniques | 1999 |
| Gregory Isaacs | Joy | Mi King | Xterminator | 1999 |
| Gregory Isaacs | Love Me Tonight | Love In The House | High Power | 1999 |
| Gregory Isaacs | Miss Claude | Grumbler | Jammy's | 1999 |
| Gregory Isaacs | More Attention | Stealing | High Power | 1999 |
| Gregory Isaacs | Tell Me Why | I Don't Want To Be No General | Cali Bud | 1999 |
| Gregory Isaacs | A Friend Of Mine | Till It Some More | Xterminator | 1998 |
| Gregory Isaacs | Bust Me Case | Bigger Boss | Arrows | 1998 |
| Gregory Isaacs | Claudette | Scull | Run Things | 1998 |
| Gregory Isaacs | False Evidence | Rocking Time (1) | High Power | 1998 |
| Gregory Isaacs | General Is Back | Praises (1) | 321 Strong | 1998 |
| Gregory Isaacs | Love A New | Give It Up | 321 Strong | 1998 |
| Gregory Isaacs | Nice Me Up | He Prayed | High Power | 1998 |
| Gregory Isaacs | No Matter | I Love King Selassie | Jammy's | 1998 |
| Gregory Isaacs | Run Johnny | Cool And Deadly | Jammy's | 1998 |
| Gregory Isaacs | Time Is The Master | Better | WWS | 1998 |
| John Holt & Gregory Isaacs | Body Language | I'm Not A King | Digital-B | 1997 |
| Gregory Isaacs | Cease Fire | Declaration Of Rights | 321 Strong | 1997 |
| Gregory Isaacs | Coke Seller | Babylon Cowboy | Xterminator | 1997 |
| Gregory Isaacs | Coward | Whip (2) | Jammy's | 1997 |
| Gregory Isaacs | Danger In Your Eyes | Danger In Your Eyes | Digital-B | 1997 |
| Gregory Isaacs & Silver Cat | One Half Affair | Bobby Babylon | Joe Gibbs | 1997 |
| Gregory Isaacs | One Half Love | Bobby Babylon | Joe Gibbs | 1997 |
| Gregory Isaacs | So Much Love | Just Like A River | Joe Gibbs | 1997 |
| Gregory Isaacs | Why | Hucks | Jammy's | 1997 |
| Gregory Isaacs | Got To Make It Up | Rain From The Skies | Bear's | 1996 |
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